| Customization: | Available |
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| CAS No.: | 3681-99-0 |
| Formula: | N/a |
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Puerarin is an isoflavone compound derived from the traditional Chinese medicine plant, Pueraria lobata. It has been the subject of extensive research due to its multifaceted pharmacological effects and its potential as a therapeutic agent for a variety of neurological disorders .
Preliminary studies have shown that puerarin exhibits neuroprotective effects in numerous models of neurological disorders, including but not limited to ischemic cerebrovascular disease, subarachnoid hemorrhage, epilepsy, cognitive disorders, traumatic brain injury, Parkinson's disease, Alzheimer's disease, anxiety, depression, diabetic neuropathy, and certain types of brain tumors like neuroblastoma and glioblastoma .
The molecular mechanisms behind puerarin's neuroprotective actions are diverse and include anti-apoptosis, inhibition of proinflammatory mediators, regulation of autophagy, anti-oxidative stress, mitochondrial protection, inhibition of calcium influx, and anti-neurodegenerative activities .
While the benefits of puerarin in pre-clinical studies are promising, there is a call for well-designed, high-quality, large-scale, multicenter randomized clinical studies to determine the safety and clinical utility of puerarin in patients with neurological disorders .
In terms of ophthalmology, puerarin has shown potential in treating various eye diseases by modulating different signaling pathways, such as NF-κB, MAPKs, PI3K/AKT, JAK/STAT, and PKC. These pathways are related to the expression of cytokines that result in anti-inflammatory, antioxidant, and anti-apoptotic effects, which are crucial in managing ocular diseases like diabetic retinopathy and glaucoma .
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