| Customization: | Available |
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| Transport Package: | Drum |
| Specification: | 99% |
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Guanidine hydrochloride, with the chemical formula CH6ClN3 and a molecular weight of 95.53, is a white or slightly yellow crystalline solid. It is known for its strong basicity and hygroscopic nature. This compound is widely used in various fields, including medicine, chemical industry, and biological sciences.
In the medical field, guanidine hydrochloride has significant applications. It can lower blood glucose levels by promoting the release of insulin, making it useful for treating type 2 diabetes. Additionally, it is employed in the treatment of hyperthyroidism and hypothyroidism by inhibiting the synthesis and release of thyroid hormones. It is also used in the treatment of adrenal cortical insufficiency and other conditions.
In the chemical industry, guanidine hydrochloride serves as an essential organic synthesis intermediate. It can react with aldehydes, ketones, and other compounds to form corresponding guanidine derivatives, which are valuable in organic synthesis. Furthermore, it is used in the preparation of nitrogen-containing heterocycles like triazines and pyrroles, which have broad applications in medicine and agriculture.
In biological sciences, guanidine hydrochloride acts as a strong ionic protein denaturant. It can dissolve insoluble or denatured proteins, such as inclusion bodies, and is used for initial protein folding and extraction of total cellular RNA. Due to its ability to disrupt protein structures, it is often referred to as a dissociating buffer when used in conjunction with other chemicals.
Guanidine hydrochloride is also used in the denaturation and reduction of proteins, facilitating research into their structure and function. In proteomics, it aids in protein lysis and digestion, providing samples for analysis.
The compound is typically prepared industrially by heating dicyandiamide with an excess of ammonia. It is generally used in salt form due to its instability in basic conditions, where it can hydrolyze to ammonia and urea, but it is more stable in acidic conditions.
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